1-Methyl-4-pyrazole Boronic Acid Pinacol Ester CAS 761446-44-0: A Buying Guide for Research and Bulk Procurement

When I purchase 1-Methyl-4-pyrazole boronic acid pinacol ester, CAS 761446-44-0, I treat it as a specialty pharmaceutical intermediate and cross-coupling building block rather than as a general laboratory reagent. The most important buying decisions are product identity, batch-specific quality documentation, packaging, storage, lead time, and the supplier’s ability to support repeat procurement. Maison Chemical supplies this compound for research, process development, and bulk sourcing, with commercial terms and documentation confirmed according to the required grade and quantity.

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This guide explains how I would evaluate the material, compare supplier responses, prepare an effective inquiry, and reduce avoidable sourcing risks. Because specifications can vary by manufacturer and application, I recommend confirming the required purity, analytical method, packaging, and delivery conditions before placing an order.

Key Takeaways

• CAS 761446-44-0 should be used as the primary identifier, together with the chemical name and structure.
• The compound is generally evaluated as a pyrazole boronic acid pinacol ester used in synthetic chemistry and medicinal chemistry workflows.
• Buyers should request a batch-specific COA, analytical data, safety documentation, storage guidance, and a clear quotation.
• Research quantities and bulk procurement require different assessments of packaging, consistency, lead time, and supply continuity.
• Maison Chemical can review technical and commercial requirements before confirming availability, MOQ, lead time, and export arrangements.

Who This Buying Guide Is For

I have prepared this guide for medicinal chemistry teams, pharmaceutical intermediate buyers, contract research organizations, university laboratories, process development groups, and distributors. It is also relevant to procurement professionals who need to compare multiple offers for CAS 761446-44-0. The appropriate purchasing approach depends on whether the material is needed for route scouting, analytical research, scale-up, or recurring production.

For small-scale research, the main priority is usually reliable identity and practical delivery in a suitable package. For process or bulk procurement, I place greater emphasis on lot-to-lot consistency, documentation, production planning, packaging integrity, and the supplier’s ability to support repeat orders. A low initial price does not necessarily represent the lowest total sourcing cost if technical clarification or replacement material becomes necessary.

What Is 1-Methyl-4-pyrazole Boronic Acid Pinacol Ester?

1-Methyl-4-pyrazole boronic acid pinacol ester, CAS 761446-44-0, is an organoboron compound containing a methyl-substituted pyrazole ring and a boronic acid pinacol ester functionality. In synthetic chemistry, this type of compound is commonly considered a coupling partner for carbon–carbon bond formation, particularly in palladium-catalyzed Suzuki-type reactions. The actual suitability depends on the reaction design, catalyst system, solvent, base, temperature, and substrate combination.

The pinacol ester form is used because it provides a practical protected form of the boronic acid functionality for handling and synthetic planning. However, I do not recommend assuming that every batch will behave identically in every reaction without checking its analytical profile and conducting appropriate laboratory evaluation. Buyers should regard published reaction examples as starting points rather than guaranteed performance specifications.

How the Product Is Used

Medicinal Chemistry and Research Synthesis

Research teams may use this building block when introducing a methyl-pyrazole-containing fragment into a larger molecular structure. It can be relevant to analogue generation, lead optimization, and route exploration where a heteroaryl boron reagent is required. The final reaction performance must be verified in the buyer’s own system because the electronic and steric properties of the coupling partners can influence conversion and selectivity.

Process Development and Intermediate Manufacturing

Process chemists may evaluate the material during route development before selecting a larger-scale supply strategy. At this stage, I recommend discussing impurity control, reaction compatibility, isolation requirements, and the expected consumption rate with the supplier. A supplier that can provide consistent batches and practical technical communication can help reduce interruptions between laboratory development and manufacturing.

Product Options and Specification Considerations

Not every buyer needs the same commercial specification. A research user may accept a standard laboratory package with a suitable COA, while a manufacturing buyer may require a defined purity target, impurity profile, residual solvent information, water content, packaging qualification, and change-control communication. I recommend defining these requirements before requesting a formal quotation.

As practical reference points, I would ask whether the commercial specification uses a purity target such as 95% or higher, whether a 1 g research package is available, and whether the supplier can quote quantities above 1 kg for scale-up. These figures are purchasing examples, not claims about the specification or package size of every batch. The final requirements should be agreed in writing before order confirmation.

A Step-by-Step Purchasing Process

1. Define the Intended Use

First, I identify whether the compound is intended for screening, route development, process validation, or production. I also estimate the quantity required for the first order and the likely annual or project demand. This information allows the supplier to recommend a more appropriate package and commercial route without making assumptions about the application.

2. Confirm Product Identity and Analytical Needs

I use the CAS number, full chemical name, and, where possible, a structure or internal material code to avoid confusion. I then specify the required purity method, analytical documents, and any limits for water, residual solvents, metals, or related substances. If a particular internal method is mandatory, I provide it during the inquiry instead of asking the supplier to interpret an unclear requirement.

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3. Request a Complete Commercial Offer

A useful inquiry should include quantity, destination country, preferred package, required delivery date, documentation needs, and whether the order may become recurring. I ask suppliers to separate product price, packaging, shipping, and any applicable export or handling charges. I also request the quotation validity period because specialty chemical pricing and availability may change with production planning.

4. Review Samples or Technical Documents

For a new supplier, I consider reviewing a sample or representative analytical package before committing to a larger order. I compare the COA format, batch number, test methods, and reported results with my internal requirements. If the supplier cannot answer basic identity, storage, or documentation questions clearly, I treat that as a sourcing risk.

5. Confirm Supply Continuity

For recurring demand, I ask about production scheduling, standard lead time, available inventory, minimum order quantity, and the process for future lots. I also clarify whether changes in manufacturing site, raw materials, analytical methods, or packaging will be communicated. This step is especially important when the compound is part of a time-sensitive synthetic route.

How to Evaluate a Supplier

I evaluate suppliers on more than price. A reliable B2B supplier should be able to identify CAS 761446-44-0 accurately, explain the available grade, provide appropriate batch documentation, and state commercial limitations clearly. I also consider response quality, export experience, packaging practices, and whether the supplier can support both small research orders and larger procurement discussions.

Maison Chemical supports inquiries for 1-Methyl-4-pyrazole boronic acid pinacol ester as a manufacturer, supplier, and exporter of pharmaceutical intermediates. We can review the requested quantity, target specification, destination, packaging, and documentation before confirming a commercial offer. Availability, MOQ, lead time, and final terms should always be verified for the specific order because they may depend on production status and customer requirements.

Pricing, MOQ, and Lead-Time Questions

Buyers should not compare two quotations unless the specification and commercial basis are equivalent. I check whether the offer refers to the same purity requirement, package size, Incoterm, payment condition, documentation set, and delivery destination. A quotation for a small research package may not be directly comparable with a bulk quotation based on scheduled production.

When discussing MOQ, I explain the project stage and expected consumption rather than requesting only the lowest possible quantity. For development work, a staged purchase may reduce inventory exposure, while a confirmed recurring forecast may help the supplier plan production more effectively. I also ask whether the quoted lead time begins after payment, order confirmation, technical approval, or production release.

Common Buying Mistakes

• Using only a product name without confirming CAS 761446-44-0 and the molecular structure.
• Accepting a purity statement without reviewing the analytical method and batch-specific result.
• Comparing prices without checking freight, packaging, taxes, Incoterms, and documentation costs.
• Waiting until the last minute to ask about lead time for a material needed in a scheduled synthesis.
• Assuming a research-grade material automatically satisfies a process or manufacturing specification.
• Failing to request storage and handling information before the material arrives.

Recommended Buyer Checklist

Before placing an order, I recommend confirming the following items in writing: product name, CAS number, quantity, purity requirement, packaging, batch documentation, storage guidance, delivery address, Incoterm, payment terms, and expected shipment date. If the material will be used in a regulated or quality-controlled environment, I also define any additional vendor qualification or change-notification requirements. Clear documentation at the inquiry stage usually prevents avoidable commercial and technical delays.

I also recommend retaining the quotation, approved specification, COA, SDS, purchase order, and shipping documents together in the project file. For repeat procurement, I compare each new lot against the previously agreed requirements rather than relying only on the supplier’s historical performance. This approach supports traceability without making unsupported assumptions about future batches.

Conclusion and Next Steps

1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0 can be a useful heteroaryl boron building block for research synthesis, medicinal chemistry, and process development. The best purchasing decision depends on matching the grade and documentation to the intended use, then evaluating the supplier’s consistency, communication, packaging, lead time, and commercial terms. I would not select a source on price alone when the material is important to a larger synthetic program.

To begin, prepare an inquiry containing the CAS number, required quantity, purity target, destination, delivery timing, packaging preference, and documentation requirements. Send these details to Maison Chemical so we can assess the request and provide availability, MOQ, lead time, specification information, and a tailored quotation. This structured approach gives research and bulk procurement teams a clearer basis for technical approval and purchasing decisions.

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