What Is Pyridine-4-boronic Acid CAS 1692-15-5? Uses, Specifications, and Supplier Information

Pyridine-4-boronic acid, also known as 4-pyridylboronic acid, is a heteroaryl boronic acid used mainly as a building block in organic synthesis. Its CAS Registry Number is 1692-15-5, and its molecular formula is commonly represented as C₅H₆BNO₂, with a calculated molecular weight of approximately 122.92 g/mol. In practical terms, I would describe it as a pyridine ring bearing a boronic acid group at the 4-position, making it useful for carbon–carbon bond-forming reactions, especially Suzuki–Miyaura coupling.

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For B2B buyers, the most important considerations are identity confirmation, assay, water content, packaging, storage, batch consistency, and the supplier’s ability to provide documentation. At Maison Chemical, I help customers evaluate Pyridine-4-boronic acid according to their synthetic route, quality requirements, regulatory expectations, and planned purchasing volume.

What Is Pyridine-4-boronic Acid?

Pyridine-4-boronic acid is an organoboron compound that combines two useful structural features: a nitrogen-containing pyridine ring and a reactive boronic acid group. The pyridine nitrogen can contribute to polarity and coordination behavior, while the boronic acid group can participate in cross-coupling chemistry after reaction with a suitable aryl or vinyl halide. This combination makes the material relevant to medicinal chemistry, pharmaceutical intermediate development, and research into functional organic molecules.

The compound is generally handled as a solid chemical intermediate. However, physical appearance, crystallinity, residual solvent, water content, and stability can vary with manufacturing and packaging conditions. I therefore recommend that buyers confirm the exact specification and current Certificate of Analysis rather than relying only on a catalog description.

Core Functions in Organic Synthesis

Suzuki–Miyaura Coupling

The primary synthetic role of Pyridine-4-boronic acid is as a coupling partner in Suzuki–Miyaura reactions. Under an appropriate catalytic system, the boronic acid functionality can react with aryl, heteroaryl, or vinyl halides to form a new carbon–carbon bond. This allows chemists to introduce a pyridin-4-yl fragment into more complex molecular structures.

The actual reaction performance depends on the substrate, palladium catalyst, base, solvent, temperature, reaction time, and concentration. I do not treat a high assay value alone as a guarantee of successful coupling, because trace metals, water, residual solvents, particle properties, and substrate-specific chemistry can also influence results.

Heteroaryl Building-Block Design

The pyridine ring provides a nitrogen-containing aromatic unit that is frequently explored in active pharmaceutical ingredient research and advanced intermediate synthesis. It can influence molecular polarity, hydrogen-bond acceptance, coordination behavior, and the overall electronic properties of a target molecule. For this reason, buyers may select this compound when they need a compact, functionalized heteroaryl component rather than a simple phenyl boronic acid.

Common Application Scenarios

• Medicinal chemistry: I commonly see this type of intermediate considered for the preparation of small-molecule libraries and candidate compounds containing pyridyl substituents.
• Pharmaceutical intermediate development: It may be used in route scouting and process development when a 4-pyridyl group is required in the target structure.
• Specialty organic synthesis: Research teams can use it to prepare more complex heteroaryl compounds for further functionalization or evaluation.
• Process chemistry: Development groups may assess it during scale-up studies, where impurity control, filtration, drying, and reproducible supply become important.
• Custom synthesis: Contract research and manufacturing organizations may include it in multistep synthesis programs that require reliable intermediate sourcing.

These applications should be understood as chemistry-use categories rather than guaranteed end uses for every project. Before purchasing, I recommend confirming the intended reaction, the required amount, the acceptable impurity profile, and whether the material will be used for exploratory research or a controlled production process.

Types and Material Options Buyers May Consider

Buyers may encounter different commercial presentations of Pyridine-4-boronic acid, including research-scale packs, development quantities, and larger production-oriented lots. The chemical identity may remain the same while the packaging, documentation package, inspection process, and release criteria differ. A development project may prioritize fast sample availability, whereas a manufacturing program may prioritize lot-to-lot consistency and supply continuity.

Some customers also compare the free boronic acid with related protected or alternative boron-containing intermediates. The correct choice depends on reaction conditions and process requirements. I advise customers not to substitute a pinacol ester or another pyridyl boronic acid automatically, because differences in reactivity, solubility, hydrolytic behavior, molecular weight, and purification can affect the route.

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Key Specifications for Pyridine-4-boronic Acid CAS 1692-15-5

A buyer should distinguish between identity information, release specifications, and observed batch results. The table below provides a practical sourcing framework; it does not replace the supplier’s current technical data sheet or Certificate of Analysis.

Because boronic acids can be sensitive to moisture, heat, and prolonged exposure to unsuitable conditions, I recommend keeping the material in its original, tightly closed packaging until use. Storage at 2–8 °C may be recommended for some supplier-controlled products, but buyers should follow the product label and SDS rather than applying one temperature rule to every batch. The receiving team should also inspect the package condition and compare the lot number with the accompanying documentation.

How to Select a Supplier

Quality and Documentation

My first selection criterion is traceable quality documentation. A dependable supplier should be able to discuss the available specification, batch testing, packaging, SDS, and Certificate of Analysis without making unsupported claims. For regulated or highly controlled projects, I also suggest asking whether analytical methods, change-control procedures, and retained-sample practices are available for review.

Supply Capability and Commercial Fit

Price is only one part of the sourcing decision. I evaluate minimum order quantity, sample policy, production scale, lead time, shipping conditions, export documentation, and the supplier’s ability to support repeat orders. A lower initial price may not be beneficial if the material is unavailable when the project moves from screening to process development.

Technical Communication

Technical responsiveness is especially important for specialty intermediates. I expect a supplier to clarify whether a quoted material is a standard product, a custom manufacturing item, or a batch-specific offer. At Maison Chemical, I can help customers review the required grade, quantity, packaging, documentation, and delivery destination before preparing a commercial quotation.

Supplier Support from Maison Chemical

Maison Chemical supplies Pyridine-4-boronic acid CAS 1692-15-5 for customers involved in research, intermediate development, and chemical manufacturing. I support the purchasing process by confirming product identity, discussing target purity, reviewing packaging needs, and aligning the quotation with the customer’s intended application. Where a project has special requirements, I encourage buyers to communicate them before order confirmation.

For a meaningful quotation, I recommend sending the requested quantity, destination country, required specification, preferred packaging, target delivery schedule, and documentation needs. If the material will be used in a sensitive coupling route, it is also useful to identify any limits for water, metals, residual solvents, or related compounds. This information allows me to provide a more relevant supply proposal instead of a generic catalog response.

Key Takeaways

• Pyridine-4-boronic acid is a heteroaryl boronic acid identified by CAS 1692-15-5.
• Its commonly represented molecular formula is C₅H₆BNO₂, with an approximate molecular weight of 122.92 g/mol.
• Its principal use is as a pyridyl building block in Suzuki–Miyaura and related organic synthesis.
• Buyers should evaluate assay, water, residual solvents, trace metals, packaging, storage, documentation, MOQ, and lead time.
• Maison Chemical can support specification review and B2B quotation requests for this product.

Conclusion: Is Pyridine-4-boronic Acid Right for Your Project?

Pyridine-4-boronic acid CAS 1692-15-5 is a practical choice when a synthesis requires the introduction of a pyridin-4-yl group through boronic-acid-based coupling chemistry. Its value comes from the combination of a reactive boronic acid group and a nitrogen-containing aromatic ring, but successful sourcing depends on more than the product name. I recommend matching the specification to the reaction, confirming current batch documentation, and reviewing moisture, impurity, packaging, and delivery requirements before purchase.

As the next step, send Maison Chemical your required quantity, purity target, destination, and documentation expectations. I can then help you assess the appropriate commercial grade and prepare a B2B supply quotation for Pyridine-4-boronic acid.

Contact us to discuss your requirements of Pyridine-4-boronic acid CAS 1692-15-5. Our experienced sales team can help you identify the options that best suit your needs.